Assessing oxygen limiting fermentation conditions for 2,3-butanediol production from Paenibacillus polymyxa

2,3-butanediol (2,3-BDO) is a platform chemical that can be converted to wide array of products ranging from bio-based materials sustainable aviation fuel. This produced by variety microorganisms in fermentation processes. Challenges remain for high titer 2,3-BDO production during due several parameters, but controlling oxygen one the most relevant processing parameters ensure viable product output. work investigated plant biomass sugars producer Paenibacillus polymyxa . Aerobic and limited conditions were initially evaluated using molasses-based media determine cell growth Similar then on hydrolysate pretreated sweet sorghum bagasse (SSB) contained fermentable structural polysaccharides. Fermentations molasses under aerobic found could generated, over time amount decreased conversion back into acetoin. Oxygen exhibited improved growth, only suppression acetoin occurred. Glucose depletion appeared have greater role influencing Further improvements yields utilizing detoxified SSB hydrolysate.